WHAT IS INOMAN®?

INOMAN® is a dietary supplement containing myo - Inositol,  amino acids, strong anti-oxidants, minerals and vitamins supporting sperm production (spermatogenesis). 

It all starts with healthy sperm. And of course, a healthy egg. To become pregnant, a women needs a regular menstrual cycle, regular ovulation and a healthy oocyte (egg). And HE needs to have enough sperm of normal quality and activity. The celluar micro-environement in the testis and within the sperm is an important determinant of pregnancy. Research showed that patients with Necrozoospermia (all or a significant amount of sperm in the ejaculate are dead) did show an absence or extremely low concentrations of myo – Inositol in sperm.

INOMAN® is developed specifically for the needs of men and can be used to provide additional nutrition at times of reduced intake or increased need. Studies have shown the effectiveness of its components in improving sperm quality and quantity.

 
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USAGE

Dosage of 2 caps per day is recommended, ideally, one in the morning and one in the evening with water around 30 min before or after mealtime. Please do not take with coffee or liquids with high sugar content like juices.

Warnings: Keep out of the reach of children. Do not exceed the recommended daily dose. Dietary supplements are not intended to replace a varied and balanced diet and healthy lifestyle. Store in a dry place away from direct light at room temperature.

 

COMPOSITION

L-carnitine:

Is produced naturally in the body and acts as energy substrate for spermatozoa; as a vitaminoid, L-carnitine can help improve sperm motility and sperm count.
Supporting role in spermatogenesis: Improves sperm count and motility 2,5,13,14,18


L-arginine:

An amino acid that is needed by the human body in large quantities and has shown in studies to significantly improve both sperm count and motility. Physiological activity: Essential amino acid, used in the production of nitric oxide
Supporting role in spermatogenesis: Increases sperm mobility 2,5

Vitamin E:

Antioxidant vitamin; essential for a healthy immune system; it can also improve sperm motility and the ability of sperm to penetrate an egg. Physiological activity: Antioxidant, acts against free radicals
Supporting role in spermatogenesis: Improves sperm motility and boosts the ability of sperm to unite with the egg cell2,5,6

Zinc:

In addition to acting as an antioxidant and being involved in numerous biochemical processes in the body, the trace element zinc leads to improved sperm cell density, improved progressive sperm motility and boosts the all-important testosterone level for improved spermatogenesis. Physiological activity: Antioxidant, important role in DNA synthesis and cell division
Supporting role in spermatogenesis: Increases sperm cell density, improves sperm motility, contributes to increased testosterone levels (important for spermatogenesis) 2,5,12,19,20

Folic acid (Vitamin B9):

Is essential for cell growth and cell division as well as nerve metabolism. It is also involved in the protection of the cardiovascular system. It has proven to have a positive effect on sperm quality.
Supporting role in spermatogenesis: Positive effect on sperm quality; increases sperm count in combination with zinc 7,20

Selenium:

It is important for cell protection and is a component of several antioxidant enzymes. It has been shown in several studies to significantly improve sperm motility. Physiological activity: Very important free radical scavengers
Supporting role in spermatogenesis: Improve sperm motility 2,5,16,21,22

Other ingredients balance hormonal levels and support anti - oxidative activity to protect sperm from environmental damage.

 

Most studies on the ingredients of INOMAN® show a range of benefits over a period of 3 to 6 months of twice daily use. Biochemical changes, which may not be obvious to you, can occur very quickly and lay the foundation for long term improvement.

HOW DO I KNOW INOMAN® WORKS?

 
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SPERM COUNT:

with use of myo-Inositol and antioxidants contained in INOMAN® over three months, nearly all users showed improved sperm count (on average they experienced a doubling of sperm)1.

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SPERM MORPHOLOGY (SHAPE):

with use of myo-Inositol and antioxidants contained in INOMAN® over three months, nearly all users improve their sperm morphology (n average by around 10%)1.

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SPERM MOTILITY:

with use of myo-Inositol and antioxidants contained in INOMAN® over three months, nearly all users showed improved sperm motility (on average by almost 5O%)1.

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IN ADDITION YOU MIGHT EXPERIENCE:

BLOOD PRESSURE: you may experience an improvement of blood pressure, easy and simple to measure.


WEIGHT: Many men taking INOMAN® lose a little weight over a six months period.


CHOLESTEROL: INOMAN® helps to normalise cholesterol and increase the "good" protective cholesterol HDL-C.

INSULIN: the reduction of insulin resistance and blood glucose levels cause other hormone levels to return to normal ranges.

Please keep in mind that the development of sperm in the body takes almost 3 months. Therefore, men will benefit by a continuous twice daily intake for at least 3 months.

TYPES OF SUB-FERTILITY

ASTENOSPERMIA OR ASTHENOZOOSPERMIA

Explanation: Astenospermia stands for a reduced motility of the sperm in the ejaculate. It is a condition of poor energy reservoir in sperm and / or an impaired energy pathway in sperm. Causes of poor motility may be same as for Oligospermia.
Increased motility of sperm combined with an improvement in all other sperm parameters may lead to an increase in the rate of fertilisation.

TERATOSPERMIA OR TERATOZOOSPERMIA

Explanation: Teratospermia stands for an increased level of abnormally shaped sperm (sperm morphology). Causes of poor morphology may be same as for Oligospermia.
Improved morphology of the sperm combined with an improvement in all other sperm parameters may lead to an increase in the rate of fertilisation.

 

OLIGOSPERMIA OR OLIGOZOOSPERMIA

Explanation: Oligospermia means a low sperm count in the ejaculate. It is caused by poor production of sperm and / or impaired transport of sperm.

Causes of a poor production may be found in:

  • Stress

  • Infections

  • Hormonal imbalance

  • Diabetes

  • Cancer surgery

  • Undescended testes 

  • Genetic & environmental factors

  • Alcohol or drug abuse

Causes of impaired transport may be found in:

  • Inflammation

  • Varicocele (varicose veins)

  • Genetic conditions

Increased quantity of sperm combined with an improvement in all other sperm parameters may lead to an increase in the rate of fertilisation.

OTHERS

Oligoasthenoteratozoospermia is an abnormal change of sperm with three abnormal parameters:

  • Not enough sperm (“oligo”)

  • Low motility of the sperm (“astheno”)

  • Increased levels of abnormally shaped sperm (“terato”)


DNA fragmentation is an abnormal change in DNA information within sperm. Sperm is the bearer of genetic information – it has to transport the DNA safely packed packaged into the egg.

Aspermia stands for a condition of absence of semen in the ejaculate

Azoospermia stands for a condition of absence of sperm in the ejaculate

Necrozoospermia stands for a condition where all sperm in the ejaculate are dead

Pervosemia stands for a condition of a low volume of ejaculate

 

WHICH DOC CAN HELP YOU?

The issues presented here becoming more openly discussed and more men are seeking professional help. In general, you should consult your general practitioner first and he/she may need to refer you to a specialist (Andrologist, Urologist or fertility specialist).

The initial evaluation begins by taking a thorough medical history. You will be asked questions about childhood, adolescent development and sexual behaviour in the relationship (frequency and timing of intercourse etc.). The Specialist will also perform a physical examination of your genitals and will normally perform an ultrasound examination of the testicles. In addition a blood test to evaluate relevant parameters like Testosterone, FSH, LH and Prolactin levels.


A spermatogram is an analysis of the ejaculate to check quality and quantity (sperm count, motility and morphology). This test examines the sperm quality under the microscope.

Please prepare your medical history as thoroughly as possible as it can provide important information on possible problems and sub-fertility. Tell your doctor if you ever had:

  • Severe general diseases

  • Mumps after puberty

  • Testicular injury

  • Inguinal hernia surgery

  • Varicose veins/varicocele

  • Medical treatments, because one or both testicles remained undescended

  • Bladder infections

  • Diabetes

  • Thyroid disease

  • Radiotherapy

  • Sexually transmitted diseases

  • Nicotine, alcohol or illegal drugs use

  • Possible exposure to environmental toxins

  • Mother was taking medication during pregnancy

  • Frequency of intercourse

  • Hereditary diseases in the family

Please tell your doctor if you use INOMAN and how long you have been taking it twice daily. As spermatogenesis is a process of around 3 months, your values may change over time. We want to support you and your partner in becoming pregnant. Please contact us if you have any question or need further explanation.

 

GLOSSARY

Amino acids:
are the smallest building blocks of proteins. They are vital for the human body and are (in addition to the nucleic acids) the basic building blocks of life. We distinguish between essential amino acids that are ingested with food and non-essential amino acids that are produced by the body itself.
Antioxidants:
Micronutrients can be described as antioxidants, which protect the body against aggressive oxidizing agents called “free radicals”.
Asthenozoospermia:
Reduction of sperm motility by > 50%. Sperm are either immobile or slow.
Azoospermia:
Absence of mature and immature sperm in the ejaculate
Ejaculate:
Semen from sperm and secretions from the prostate and seminal vesicles
Fertility:
Begins with puberty in young men and decreases with age. In women, it begins with menarche (first menstrual period) and ends with menopause. With increasing age we see a decrease sperm count and quality and number of eggs.
Hyposemia:
The volume of ejaculate is significantly reduced
Infertility:
According to WHO, a couple is considered infertile if after “A year of unprotected regular intercourse” no conception takes place.
Macro-and micronutrients :
Life requires energy and this can only be produced by combustion (oxidation). Macronutrients (carbohydrates, fats, proteins) that serve this process are included in the diet as an energy supplier or oxidizing agents. In order to allow a moderate oxidation, enzymes and excipients are required. These so-called adjuvants the organism cannot produce for itself, but must be taken with food as micronutrients. Food macronutrients that serve as fuel and micronutrients as essential auxiliaries are supplied by a healthy balanced diet. One can imagine that an imbalance in the supply of macro and micro nutrients can damage the body. If the fuels are increased and the auxiliaries decreased then the body may damage itself. These micronutrients can be described as protecting the body against aggressive oxidizing agents, also called “free radicals”.
Micronutrients:
Are vital substances in food and food supplements. Everyone needs a different requirement of micronutrients to include vitamins, amino acids, trace elements, minerals, fatty acids and phytochemicals. In order to keep the body strong and efficient and to promote healing, it needs the required daily amount of such nutrients.
Minerals:
Are inorganic vital nutrients that must be supplied to the body through diet (e.g. copper, selenium, zinc). There are lot of elements (found in large concentrations in the body) and trace elements (in small concentrations).
myo-Inositol:
Is a natural occurring substance in the human body and important for the insulin sensitising function of cells. It plays an important role in cellular shape and structure, in lipid manufacture, in the structure and function of cell membranes, and in cell growth (especially germ cells and spermatogenesis). Scientific evidence shows that dietary supplementation with myo - Inositol helps to improve sperm quality and quantity. Its role includes a specific biological activity regarding control of fat metabolism, sugars and cellular functions of the nervous system. In the case of insulin resistance or Type II diabetes, myo - Inositol helps to improve the overall clinical picture and is useful in preventing and correcting metabolic abnormalities and reproductive difficulties. 
Necrozoospermia:
All or a significant amount of sperm in the ejaculate is dead 
Normozoospermia:
Normal quality of sperm. The number of sperm is about 20 million per milliliter of ejaculate, 30% are normally shaped and 50% show good movement.
Oligozoospermia:
The number of sperm is significantly reduced (<10 Mill / ml ejaculate)
Sertoli cell-only syndrome:
Absence of spermatozoa.
Spermatogenesis:
Seed maturation. The development of the spermatogonia to sperm cell takes at least 64 days. It is hormonally controlled and is very sensitive to endogenous and exogenous influences. About 1000 sperm are produced per second that are approximately three to four million per hour. A balanced diet, nicotine and alcohol reduction, relaxation and regular physical activity has a positive effect on the sperm cell formation.
Semen analysis:
Provides information on semen quality and can shed light on male fertility. Since sperm quality may vary in the ejaculate for the diagnosis of “infertility” there should always be at least two semen analyses. The following parameters are evaluated: sperm density, motility, morphology.
Sperm:
Are mature germ cells (sperm).
Teratozoospermia:
> 40% dysmorphic, abnormal shaped sperm.
Varicocele:
Varicose veins in the testicles
Vitamins:
Are essential organic food ingredients. In the absence of supply, deficiency symptoms can occur (eg, vitamin E, folic acid). They are of particular important for the immune system and the nervous system and act as antioxidants to protect the body from free radicals.

 

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